Under normal circumstances, antigen-dependent antibody production in man requires autologous T cells, B cells and macrophages. If allogeneic T cells are substituted, then antibodies are not synthesized, due to the development of inhibitory interactions. Addition of B cell growth and differentiation factors change this pattern of response, and allow antibodies to be produced even when allogeneic T cells are the source of help. There is evidence that such B cell growth factors are released during most normal immune responses: we suggest that their ability to allow B cells to escape from inhibitory interactions and secrete antibodies, may underlie the observed exacerbation of certain autoimmune diseases by intercurrent infection.
|Original language||English (US)|
|Number of pages||6|
|Journal||Clinical and Experimental Immunology|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Immunology and Allergy