TY - JOUR
T1 - Human B cell growth factors overcome T cell-mediated inhibition of specific antibody production
T2 - A possible mechanism for the exacerbation of autoimmune disease
AU - Brenner, Malcolm
AU - North, M. E.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Under normal circumstances, antigen-dependent antibody production in man requires autologous T cells, B cells and macrophages. If allogeneic T cells are substituted, then antibodies are not synthesized, due to the development of inhibitory interactions. Addition of B cell growth and differentiation factors change this pattern of response, and allow antibodies to be produced even when allogeneic T cells are the source of help. There is evidence that such B cell growth factors are released during most normal immune responses: we suggest that their ability to allow B cells to escape from inhibitory interactions and secrete antibodies, may underlie the observed exacerbation of certain autoimmune diseases by intercurrent infection.
AB - Under normal circumstances, antigen-dependent antibody production in man requires autologous T cells, B cells and macrophages. If allogeneic T cells are substituted, then antibodies are not synthesized, due to the development of inhibitory interactions. Addition of B cell growth and differentiation factors change this pattern of response, and allow antibodies to be produced even when allogeneic T cells are the source of help. There is evidence that such B cell growth factors are released during most normal immune responses: we suggest that their ability to allow B cells to escape from inhibitory interactions and secrete antibodies, may underlie the observed exacerbation of certain autoimmune diseases by intercurrent infection.
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M3 - Article
C2 - 6603301
AN - SCOPUS:0020535115
SN - 0009-9104
VL - 52
SP - 635
EP - 640
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 3
ER -