HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Somik Chatterjee; Jason W. Wang; Mary J. Cismowski; John R. Bower; Kenneth Steven Rosenthal

doi:10.1007/s00705-009-0341-9

HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Somik Chatterjee, Jason W. Wang, Mary J. Cismowski, John R. Bower, Kenneth Steven Rosenthal

Academic Institute

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

Original language	English (US)
Pages (from-to)	661-663
Number of pages	3
Journal	Archives of Virology
Volume	154
Issue number	4
DOIs	https://doi.org/10.1007/s00705-009-0341-9
State	Published - Apr 2009

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Virology

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title = "HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing",

abstract = "The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.",

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T1 - HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

AU - Chatterjee, Somik

AU - Wang, Jason W.

AU - Cismowski, Mary J.

AU - Bower, John R.

AU - Rosenthal, Kenneth Steven

PY - 2009/4

Y1 - 2009/4

N2 - The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

AB - The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

UR - https://www.scopus.com/pages/publications/64249171383

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EP - 663

JO - Archives of Virology

JF - Archives of Virology

IS - 4

ER -

HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Abstract

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