TY - JOUR
T1 - HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing
AU - Chatterjee, Somik
AU - Wang, Jason W.
AU - Cismowski, Mary J.
AU - Bower, John R.
AU - Rosenthal, Kenneth Steven
PY - 2009/4
Y1 - 2009/4
N2 - The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.
AB - The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.
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U2 - 10.1007/s00705-009-0341-9
DO - 10.1007/s00705-009-0341-9
M3 - Article
C2 - 19267180
AN - SCOPUS:64249171383
SN - 0304-8608
VL - 154
SP - 661
EP - 663
JO - Archives of Virology
JF - Archives of Virology
IS - 4
ER -