Host defense antimicrobial peptides as antibiotics: design and application strategies

Biswajit Mishra, Scott Reiling, D. Zarena, Guangshun Wang

    Research output: Contribution to journalReview articlepeer-review

    239 Scopus citations

    Abstract

    This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.

    Original languageEnglish (US)
    Pages (from-to)87-96
    Number of pages10
    JournalCurrent Opinion in Chemical Biology
    Volume38
    DOIs
    StatePublished - Jun 1 2017

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry

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