@inbook{7c6688314a2e46e7a91f1b67211bc81c,
title = "Hospital-Based RNA Therapeutics",
abstract = "Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical-grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology are increasing the scope of mRNA clinical applications.",
keywords = "Circular mRNA, Hospital-based mRNA therapeutics, Messenger RNA, RNA-based CAR T cell, RNA-based gene-editing tools, Self-amplifying mRNA",
author = "Damase, {Tulsi Ram} and Roman Sukhovershin and Min Zhang and Kiss, {Daniel L.} and Cooke, {John P.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-031-08415-7_4",
language = "English (US)",
series = "RNA Technologies",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "73--92",
booktitle = "RNA Technologies",
address = "Germany",
}