Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical-grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology are increasing the scope of mRNA clinical applications.

Original languageEnglish (US)
Title of host publicationRNA Technologies
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages20
StatePublished - 2022

Publication series

NameRNA Technologies
ISSN (Print)2197-9731
ISSN (Electronic)2197-9758


  • Circular mRNA
  • Hospital-based mRNA therapeutics
  • Messenger RNA
  • RNA-based CAR T cell
  • RNA-based gene-editing tools
  • Self-amplifying mRNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Biochemistry, medical
  • Cancer Research


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