Hospital-Based RNA Therapeutics

Tulsi R. Damase; Roman Sukhovershin; Min Zhang; Daniel L. Kiss; John P. Cooke

Hospital-Based RNA Therapeutics

Tulsi R. Damase, Roman Sukhovershin, Min Zhang, Daniel L. Kiss, John P. Cooke

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology, are increasing the scope of mRNA clinical applications.

Original language	English (US)
Title of host publication	mRNA Therapeutics
Subtitle of host publication	Springer
State	Accepted/In press - Dec 14 2021

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title = "Hospital-Based RNA Therapeutics",

abstract = "Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology, are increasing the scope of mRNA clinical applications.",

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AU - Damase, Tulsi R.

AU - Sukhovershin, Roman

AU - Zhang, Min

AU - Kiss, Daniel L.

AU - Cooke, John P.

PY - 2021/12/14

Y1 - 2021/12/14

N2 - Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology, are increasing the scope of mRNA clinical applications.

AB - Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology, are increasing the scope of mRNA clinical applications.

M3 - Chapter

BT - mRNA Therapeutics

ER -

Hospital-Based RNA Therapeutics

Abstract

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