Horseshoe kidney is associated with an increased relative risk of primary renal carcinoid tumor

Bhuvaneswari Krishnan, Luan Truong, Georges Saleh, Donna M. Sirbasku, Kevin M. Slawin

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Purpose: Carcinoid tumor is a rare neoplasm of the kidney with an unknown histogenesis. Of only 31 cases previously reported in the literature 4 arose within horseshoe kidneys. We report a case of primary carcinoid tumor arising within a horseshoe kidney and discuss the unique insight it provided into the pathogenesis of this tumor. Materials and Methods: We reviewed in detail all 31 reported cases of renal carcinoid tumor and, using reported incidence rates of horseshoe kidney, we calculated the relative risk of renal carcinoid tumor arising within a horseshoe kidney. Immunohistochemical staining for neuroendocrine related markers was performed on tissue sections from the present carcinoid tumor, the adjacent kidney and 5 control samples of normal renal parenchyma. Results: Of the reported tumors 15.6% occurred in horseshoe kidneys, yielding a calculated relative risk of 62. The present tumor was multifocal, arising from the wall of a cystic lesion and possibly representing a dilated calix within the isthmus. Intestinal epithelium lining the cyst cavity exhibited multifocal neuroendocrine cell hyperplasia with an immunohistochemical profile identical to that of the carcinoid tumor cells. Conclusions: The relative risk of renal carcinoid tumor developing in a horseshoe kidney is markedly greater than that for Wilms tumor or transitional cell carcinoma. The clinical course of renal carcinoid tumor arising within a horseshoe kidney appears to be more benign than that of the nonhorseshoe variant. Our observations support the hypothesis that renal carcinoid tumors may arise from neuroendocrine cells within foci of metaplastic or teratomatous epithelium within the kidney.

Original languageEnglish (US)
Pages (from-to)2059-2066
Number of pages8
JournalJournal of Urology
Volume157
Issue number6
DOIs
StatePublished - Jun 1997

Keywords

  • carcinoid tumor
  • kidney diseases
  • kidney neoplasms

ASJC Scopus subject areas

  • Urology

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