Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women

Alexander Butkevich, Carmella Abraham, Robert A. Phillips

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Menopause is associated with an increase in blood pressure (BP) and a decrease in physiologic nocturnal BP fall. These factors may play a role in the increased risk of cardiovascular events after menopause. Some studies indicate that transdermal estrogen replacement therapy may help restore the 24-h BP profile, but data on the effect of oral conjugated estrogens are lacking. We compared 24-h ambulatory BP profiles of 42 postmenopausal women not receiving hormone replacement therapy (HRT) and 20 women receiving HRT. HRT was associated with a significant increase in the proportion of dippers (50% in women not receiving HRT and 80% in women receiving HRT, P = .048). Increase in nocturnal dipping may account, in part, for the beneficial cardiovascular effects of HRT. (C) 2000 American Journal of Hypertension, Ltd.

Original languageEnglish (US)
Pages (from-to)1039-1041
Number of pages3
JournalAmerican Journal of Hypertension
Issue number9
StatePublished - 2000


  • Blood pressure profile
  • Hormone replacement therapy
  • Menopause

ASJC Scopus subject areas

  • Internal Medicine


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