TY - JOUR
T1 - Hormone abnormalities are not related to the erectile dysfunction and decreased libido found in many men with infertility
AU - Satkunasivam, Raj
AU - Ordon, Michael
AU - Hu, Brian
AU - Mullen, Brendan
AU - Lo, Kirk
AU - Grober, Ethan
AU - Jarvi, Keith
PY - 2014/6
Y1 - 2014/6
N2 - Objective To evaluate whether hormonal markers predict erectile dysfunction (ED) and symptoms of T deficiency syndrome (TDS), which are commonly found in the population of infertile men. Design Retrospective study utilizing a prospectively maintained infertility database. Setting A tertiary referral center. Patient(s) A total of 1,750 of 2,783 men presenting for evaluation of infertility between 1995 and 2010 completed validated questionnaires. Intervention(s) Androgen Deficiency in the Aging Male (ADAM) and Sexual Health Inventory for Men questionnaires were administered. Baseline risk factors for ED and TDS were also measured. Subjects underwent serum hormone evaluation for total T, calculated bioavailable T, sex hormone-binding globulin, E2, LH, FSH, and PRL. Main Outcome Measure(s) Multivariable logistic regression modeling was used to determine the significance of hormonal markers in predicting ED (Sexual Health Inventory for Men score <22) and/or a positive ADAM score. Result(s) The prevalence of ED and a positive response to the ADAM questionnaire were 30.5% and 45.2%, respectively, in this population (mean age, 36 years). Low serum T (total T < 10 nmol/L) was found in 29.4%. Neither T nor bioavailable T was significantly associated with the symptoms of ED or TDS on multivariable regression analysis. Conclusion(s) Erectile dysfunction and TDS in young, infertile men seem to be unrelated to hormone changes.
AB - Objective To evaluate whether hormonal markers predict erectile dysfunction (ED) and symptoms of T deficiency syndrome (TDS), which are commonly found in the population of infertile men. Design Retrospective study utilizing a prospectively maintained infertility database. Setting A tertiary referral center. Patient(s) A total of 1,750 of 2,783 men presenting for evaluation of infertility between 1995 and 2010 completed validated questionnaires. Intervention(s) Androgen Deficiency in the Aging Male (ADAM) and Sexual Health Inventory for Men questionnaires were administered. Baseline risk factors for ED and TDS were also measured. Subjects underwent serum hormone evaluation for total T, calculated bioavailable T, sex hormone-binding globulin, E2, LH, FSH, and PRL. Main Outcome Measure(s) Multivariable logistic regression modeling was used to determine the significance of hormonal markers in predicting ED (Sexual Health Inventory for Men score <22) and/or a positive ADAM score. Result(s) The prevalence of ED and a positive response to the ADAM questionnaire were 30.5% and 45.2%, respectively, in this population (mean age, 36 years). Low serum T (total T < 10 nmol/L) was found in 29.4%. Neither T nor bioavailable T was significantly associated with the symptoms of ED or TDS on multivariable regression analysis. Conclusion(s) Erectile dysfunction and TDS in young, infertile men seem to be unrelated to hormone changes.
KW - Infertility
KW - andropause
KW - erectile dysfunction
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U2 - 10.1016/j.fertnstert.2014.02.044
DO - 10.1016/j.fertnstert.2014.02.044
M3 - Article
C2 - 24684954
AN - SCOPUS:84901753524
SN - 0015-0282
VL - 101
SP - 1594
EP - 1598
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -