TY - JOUR
T1 - Hormonal Regulation of Cytochrome P-450 Gene Expression
AU - Lund, Johan
AU - Zaphiropoulos, Peter G.
AU - Mode, Agneta
AU - Warner, Margaret
AU - Gustafsson, Jan Åke
N1 - Funding Information:
These authors are supported by grants from the Swedish Medical Council and the Swedish Work Health and Environment Fund.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - This chapter discusses P-450 function and regulation, which should also be of pharmacological relevance—namely, the endocrine regulation of P-450. From a pharmacological perspective, the most significant aspect of the cytochrome P-450 family of proteins is its role in the hepatic metabolism of therapeutic agents. These enzymes have a major influence on the duration of action and on the toxicity of therapeutic agents because they activate, inactivate, and facilitate the excretion of many drugs. Knowledge of the forms of P-450, their substrate specificities, and their regulation is important for the effective therapeutic use of drugs and for understanding and perhaps predicting drug interactions. Sometimes one and the same P-450 gene appears to be multihormonally regulated, indicating the necessity of fine tuning of the specific enzyme activity as a well-balanced response to the current physiological demands of the organism. Such delicate and sophisticated interactive regulatory networks certainly suggest that all P-450 genes express physiologically-essential proteins. This opens up interesting possibilities in the future for development of new therapeutic agents aimed at manipulating tissue levels of those P-450s, which have key roles in various physiological and pathophysiological processes.
AB - This chapter discusses P-450 function and regulation, which should also be of pharmacological relevance—namely, the endocrine regulation of P-450. From a pharmacological perspective, the most significant aspect of the cytochrome P-450 family of proteins is its role in the hepatic metabolism of therapeutic agents. These enzymes have a major influence on the duration of action and on the toxicity of therapeutic agents because they activate, inactivate, and facilitate the excretion of many drugs. Knowledge of the forms of P-450, their substrate specificities, and their regulation is important for the effective therapeutic use of drugs and for understanding and perhaps predicting drug interactions. Sometimes one and the same P-450 gene appears to be multihormonally regulated, indicating the necessity of fine tuning of the specific enzyme activity as a well-balanced response to the current physiological demands of the organism. Such delicate and sophisticated interactive regulatory networks certainly suggest that all P-450 genes express physiologically-essential proteins. This opens up interesting possibilities in the future for development of new therapeutic agents aimed at manipulating tissue levels of those P-450s, which have key roles in various physiological and pathophysiological processes.
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U2 - 10.1016/S1054-3589(08)60040-X
DO - 10.1016/S1054-3589(08)60040-X
M3 - Article
C2 - 1659866
AN - SCOPUS:0026275338
VL - 22
SP - 325
EP - 354
JO - Advances in Pharmacology
JF - Advances in Pharmacology
SN - 1054-3589
IS - C
ER -