Hormonal regulation of calcium transport in thick ascending limb renal tubules

Wadi N. Suki, D. Rouse

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Net calcium efflux (JCanet) was compared in isolated perfused cortical and medullary segments of the thick ascending limb of Henle of the rabbit kidney. In response to the addition of calcitonin to the bathing medium, cortical segments showed no change in JCanet, whereas in medullary segments JCanet increased significantly. Similar studies substituting 8-bromo-cyclic AMP (8-BrcAMP) in concentrations of 10(-4) M or lower in the bath showed no effect on JCanet in either segment. When the concentration of 8-BrcAMP in the bath was increased to 10(-3) M, JCanet rose significantly in both segments. These results indicate heterogeneity of response to calcitonin in the cortical and medullary segments of the thick ascending limb of Henle, but a similar response of calcium transport to cAMP. Because we have previously shown that parathyroid hormone stimulates net calcium efflux in the cortical but not in the medullary segments of the thick ascending limb of Henle, the present observations suggest that cAMP may be the mediator of the actions of both calcitonin and parathyroid hormone.

Original languageEnglish (US)
Pages (from-to)F171-F174
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume10
Issue number2
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology

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