Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study

Maria C. Rodriguez-Oroz, Pablo Martínez Lage, Jose Sanchez-Mut, Isabel Lamet, Javier Pagonabarraga, Jon B. Toledo, David García-Garcia, Pedro Clavero, Lluis Samaranch, Cecilia Irurzun, Juan M. Matsubara, Jaione Irigoien, Emilia Bescos, Jaime Kulisevsky, Jordi Pérez-Tur, Jose A. Obeso

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebro-vascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case-control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM-IV) (n = 30), compared with cognitively normal age-matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either.

Original languageEnglish (US)
Pages (from-to)1437-1444
Number of pages8
JournalMovement Disorders
Issue number10
StatePublished - Jul 30 2009


  • Dementia
  • Genetics
  • Homocysteine
  • Mild cognitive impairment
  • Parkinson's disease
  • White matter hyperintensities

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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