TY - JOUR
T1 - Homing alone? CD18 in infectious and allergic disease
AU - Lee, Seung Hyo
AU - Corry, David
PY - 2004/6/1
Y1 - 2004/6/1
N2 - CD18 (integrin β2) is an adhesion molecule that is crucial for host defense, but a comprehensive understanding of CD18 in immunity has been elusive. Studies now show that, through the control of homing and other cellular adhesive events, CD18 is important for innate (especially neutrophil-dependent) immunity but not adaptive Th1 defense mechanisms. Furthermore, Th2 cells, which are associated with allergic disease and impair the clearance of Th1-dependent pathogens, require CD18 integrins for homing to sites of inflammation. These findings suggest that the therapeutic targeting of CD18 integrins to exclude the homing of pathogenic Th2 cells might be effective in the treatment of allergic and Th1-dependent infectious diseases.
AB - CD18 (integrin β2) is an adhesion molecule that is crucial for host defense, but a comprehensive understanding of CD18 in immunity has been elusive. Studies now show that, through the control of homing and other cellular adhesive events, CD18 is important for innate (especially neutrophil-dependent) immunity but not adaptive Th1 defense mechanisms. Furthermore, Th2 cells, which are associated with allergic disease and impair the clearance of Th1-dependent pathogens, require CD18 integrins for homing to sites of inflammation. These findings suggest that the therapeutic targeting of CD18 integrins to exclude the homing of pathogenic Th2 cells might be effective in the treatment of allergic and Th1-dependent infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=2642548071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2642548071&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2004.04.002
DO - 10.1016/j.molmed.2004.04.002
M3 - Article
C2 - 15177189
AN - SCOPUS:2642548071
SN - 1471-4914
VL - 10
SP - 258
EP - 262
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 6
ER -