Homeobox genes and connective tissue patterning

Guillermo Oliver, Roland Wehr, Nancy A. Jenkins, Neal G. Copeland, Benjamin N.R. Cheyette, Volker Hartenstein, S. Lawrence Zipursky, Gruss Peter Gruss

Research output: Contribution to journalArticlepeer-review

286 Scopus citations


In vertebrates, limb tendons are derived from cells that migrate from the lateral plate mesoderm during early development. While some of the developmental steps leading to the formation of these tissues are known, little is known about the molecular mechanisms controlling them. We have identified two murine homeobox-containing genes, Six 1 and Six 2, which are expressed in a complementary fashion during the development of limb tendons. Transcripts for both genes are found in different sets of phalangeal tendons. Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes.

Original languageEnglish (US)
Pages (from-to)693-705
Number of pages13
Issue number3
StatePublished - Mar 1 1995


  • Connective tissue
  • Embryogenesis
  • Homeobox
  • Limb
  • Murine
  • Muscle
  • Splotch
  • Tendons

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology


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