Hollow Mesoporous Metal-Organic Framework Microdisks via a Solid Template-Based Approach and Post-Synthetic Wet-Chemical Etching for Protein Loading

Guixian Zhu, Lin Cheng, Ruogu Qi, Xuewu Liu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Metal-organic frameworks (MOFs), with high crystalline and ordered pore structures, hold great potential for various applications. However, the small microporous structures of MOFs restrict their applications. MOFs with larger porous structure and dimensions can expand their functionality to integrate with other large active agents. By applying porous silicon microdisks (PSi) as hard templates, zeolitic imidazolate frameworks (ZIFs) were assembled on PSi to form PSi@ZIF-8 core-shell microdisks. A new porous structure of ZIF-8 microcages was obtained via a post-synthetic approach. The influence of PSi and reaction precursor for ZIF-8 were explored, and the formation mechanism of mesoporous ZIF-8 (PZIF-8) hollow microcages was also proposed. By applying bovine serum albumin (BSA) as a loading agent, the protein release behavior of PSi@PZIF-8 was investigated. It is noted that prepared PZIF-8 microcages could serve as new vectors for loading active agents.

Original languageEnglish (US)
Pages (from-to)589-597
Number of pages9
JournalChemNanoMat
Volume6
Issue number4
DOIs
StatePublished - Apr 1 2020

Keywords

  • metal-organic frameworks
  • microcage
  • porous silicon microdisks
  • post-synthetic
  • protein loading

ASJC Scopus subject areas

  • Biomaterials
  • Renewable Energy, Sustainability and the Environment
  • Energy Engineering and Power Technology
  • Materials Chemistry

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