HLA-DR2 and white matter lesion distribution in MS

Jorge Sepulcre; Joseph C. Masdeu; Ricardo Palacios; Joaquín Goñi; Beatriz Moreno; Mikel Tainta; Bartolomé Bejarano; Pablo Villoslada

doi:10.1111/j.1552-6569.2008.00259.x

HLA-DR2 and white matter lesion distribution in MS

Jorge Sepulcre, Joseph C. Masdeu, Ricardo Palacios, Joaquín Goñi, Beatriz Moreno, Mikel Tainta, Bartolomé Bejarano, Pablo Villoslada

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.

Original language	English (US)
Pages (from-to)	328-331
Number of pages	4
Journal	Journal of Neuroimaging
Volume	18
Issue number	3
DOIs	https://doi.org/10.1111/j.1552-6569.2008.00259.x
State	Published - Jul 2008

Keywords

HLA-DR2
Lesion distribution
MRI
Multilple sclerosis

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Neuroscience(all)
Radiological and Ultrasound Technology

Access to Document

10.1111/j.1552-6569.2008.00259.x

Cite this

@article{98481bf6e9014868a3bbbcf64f95e14c,

title = "HLA-DR2 and white matter lesion distribution in MS",

abstract = "Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.",

keywords = "HLA-DR2, Lesion distribution, MRI, Multilple sclerosis",

author = "Jorge Sepulcre and Masdeu, {Joseph C.} and Ricardo Palacios and Joaqu{\'i}n Go{\~n}i and Beatriz Moreno and Mikel Tainta and Bartolom{\'e} Bejarano and Pablo Villoslada",

year = "2008",

month = jul,

doi = "10.1111/j.1552-6569.2008.00259.x",

language = "English (US)",

volume = "18",

pages = "328--331",

journal = "Journal of Neuroimaging",

issn = "1051-2284",

publisher = "Wiley",

number = "3",

}

TY - JOUR

T1 - HLA-DR2 and white matter lesion distribution in MS

AU - Sepulcre, Jorge

AU - Masdeu, Joseph C.

AU - Palacios, Ricardo

AU - Goñi, Joaquín

AU - Moreno, Beatriz

AU - Tainta, Mikel

AU - Bejarano, Bartolomé

AU - Villoslada, Pablo

PY - 2008/7

Y1 - 2008/7

N2 - Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.

AB - Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.

KW - HLA-DR2

KW - Lesion distribution

KW - MRI

KW - Multilple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=51349150270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349150270&partnerID=8YFLogxK

U2 - 10.1111/j.1552-6569.2008.00259.x

DO - 10.1111/j.1552-6569.2008.00259.x

M3 - Article

C2 - 18482373

AN - SCOPUS:51349150270

SN - 1051-2284

VL - 18

SP - 328

EP - 331

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

IS - 3

ER -

HLA-DR2 and white matter lesion distribution in MS

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this