HIV-related Hodgkin's disease with central nervous system involvement and association with Epstein-Barr virus

Suleiman Massarweh, Mark M. Udden, Imran Shahab, Michael Kroll, David A. Sears, Garrett R. Lynch, Bin S. Teh, Hsin H. Lu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Central nervous system (CNS) involvement is a rare occurrence in the course of human immunodeficiency virus (HIV)-related Hodgkin's disease (HD). We report the clinical course of a patient with HIV infection who developed systemic HD, mixed cellularity subtype, later complicated by leptomeningeal involvement. The patient died from his illness, and autopsy was performed. Examining the brain lesion, Epstein-Barr virus (EBV) presence was demonstrated in Reed-Sternberg cells by immunohistochemistry using an EBER probe for EBV RNA. This is the second case report in the English literature of HD involving the CNS in an HIV-positive individual, and the first demonstrating EBV presence. Extranodal presence of Hodgkin's disease in patients with HIV infection is probably related to immunosuppression, and physicians treating this illness should be alert to the potential of unusual sites of involvement.

Original languageEnglish (US)
Pages (from-to)216-219
Number of pages4
JournalAmerican Journal of Hematology
Volume72
Issue number3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Autopsy
  • Central nervous system
  • Epstein-Barr virus
  • Hodgkin's disease
  • Human Immunodeficiency virus

ASJC Scopus subject areas

  • Hematology

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