Historical overview of nuclear receptors

Jan Ake Gustafsson

doi:10.1016/j.jsbmb.2015.03.004

Historical overview of nuclear receptors

Jan Ake Gustafsson

Houston Methodist

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.

Original language	English (US)
Pages (from-to)	3-6
Number of pages	4
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	157
DOIs	https://doi.org/10.1016/j.jsbmb.2015.03.004
State	Published - Mar 1 2016

Keywords

Domain structure
Orphan receptor
Steroid response element

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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10.1016/j.jsbmb.2015.03.004

Cite this

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abstract = "This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.",

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Historical overview of nuclear receptors

Abstract

Keywords

ASJC Scopus subject areas

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