Historical overview of nuclear receptors

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32 Scopus citations

Abstract

This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.

Original languageEnglish (US)
Pages (from-to)3-6
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume157
DOIs
StatePublished - Mar 1 2016

Keywords

  • Domain structure
  • Orphan receptor
  • Steroid response element

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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