Historical overview of nuclear receptors

Jan Ake Gustafsson

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.

Original languageEnglish (US)
Pages (from-to)3-6
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
StatePublished - Mar 1 2016


  • Domain structure
  • Orphan receptor
  • Steroid response element

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology


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