Historical and modern approaches to chemotherapy for retinoblastoma

Amy C. Schefler, Maria Elena Jockovich, Stuart Toledano, Timothy G. Murray

Research output: Contribution to journalArticle

Abstract

Although the survival rates of retinoblastoma patients in the USA and other developed nations approach 98% and globe salvage rates have increased dramatically over time, many challenges still face both the ocular and pediatric oncologists who care for the patients with this disease. In this review, we discuss the current strategy for the utilization of chemotherapeutic agents for retinoblastoma, including intravenous delivery, subconjunctival injections and intra-arterial administration. We also review the current uses of chemotherapy for metastatic disease. The challenges and complications encountered with chemotherapeutic treatment strategies in this unique patient population will be discussed. Finally, we address the novel pharmacotherapies and delivery systems currently being explored in the laboratory that will soon be critical in clinical settings.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalExpert Review of Ophthalmology
Volume1
Issue number1
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • animal models
  • antiangiogenesis
  • carboplatin
  • chemotherapy
  • etoposide
  • intraocular retinoblastoma
  • metastatic retinoblastoma
  • subconjunctival
  • vincristine

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

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