@inbook{72f38ca214a04fea9109d9f42a3af1fc,
title = "Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development",
abstract = "Epigenetic marks, such as DNA methylation and posttranslational modifications of core histones, are the key regulators of gene expression. In the mouse, many of these marks are erased during gamete formation and must be introduced de novo after fertilization. Some of them appear synchronously, but the others are deposited asynchronously and/or remain differently distributed on maternal and paternal chromatin. Although the mechanisms regulating these processes are not entirely understandable, it is commonly accepted that epigenetic reprogramming occurring during the first cell cycle of a mouse embryo is crucial for its further development. This chapter focuses on selected epigenetic modifications, such as DNA methylation, the introduction of histone variants, histones acetylation, phosphorylation, and methylation. Properly depositing these marks on maternal and paternal chromatin is crucial for normal embryonic development.",
keywords = "Chromosome segregation, Epigenetic marks, Gene expression, Maternal chromatin, Paternal chromatin, Preimplantation development, ZGA, Zygote",
author = "Ewa Borsuk and Julia Michalkiewicz and Kubiak, \{Jacek Z.\} and Malgorzata Kloc",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/978-3-031-06573-6\_14",
language = "English (US)",
series = "Results and Problems in Cell Differentiation",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "397--415",
booktitle = "Results and Problems in Cell Differentiation",
address = "Germany",
}