Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development

Ewa Borsuk, Julia Michalkiewicz, Jacek Z. Kubiak, Malgorzata Kloc

Research output: Chapter in Book/Report/Conference proceedingChapter


Epigenetic marks, such as DNA methylation and posttranslational modifications of core histones, are the key regulators of gene expression. In the mouse, many of these marks are erased during gamete formation and must be introduced de novo after fertilization. Some of them appear synchronously, but the others are deposited asynchronously and/or remain differently distributed on maternal and paternal chromatin. Although the mechanisms regulating these processes are not entirely understandable, it is commonly accepted that epigenetic reprogramming occurring during the first cell cycle of a mouse embryo is crucial for its further development. This chapter focuses on selected epigenetic modifications, such as DNA methylation, the introduction of histone variants, histones acetylation, phosphorylation, and methylation. Properly depositing these marks on maternal and paternal chromatin is crucial for normal embryonic development.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages19
StatePublished - 2022

Publication series

NameResults and Problems in Cell Differentiation
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412


  • Chromosome segregation
  • Epigenetic marks
  • Gene expression
  • Maternal chromatin
  • Paternal chromatin
  • Preimplantation development
  • ZGA
  • Zygote

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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