Histone modifications are associated with 9-tetrahydrocannabinol-mediated alterations in antigenspecific t cell responses

Xiaoming Yang; Venkatesh L. Hegde; Roshni Rao; Jiajia Zhang; Prakash S. Nagarkatti; Mitzi Nagarkatti

doi:10.1074/jbc.M113.545210

Histone modifications are associated with 9-tetrahydrocannabinol-mediated alterations in antigenspecific t cell responses

Xiaoming Yang, Venkatesh L. Hegde, Roshni Rao, Jiajia Zhang, Prakash S. Nagarkatti, Mitzi Nagarkatti

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Background: Marijuana has been shown to have an immunomodulatory activity. Results: ChIP-Seq results show genome-wide changes in histone methylation in immune cells treated with THC. Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response. Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.

Original language	English (US)
Pages (from-to)	18707-18718
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M113.545210
State	Published - Jul 4 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Histone modifications are associated with 9-tetrahydrocannabinol-mediated alterations in antigenspecific t cell responses",

abstract = "Background: Marijuana has been shown to have an immunomodulatory activity. Results: ChIP-Seq results show genome-wide changes in histone methylation in immune cells treated with THC. Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response. Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.",

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AU - Yang, Xiaoming

AU - Hegde, Venkatesh L.

AU - Rao, Roshni

AU - Zhang, Jiajia

AU - Nagarkatti, Prakash S.

AU - Nagarkatti, Mitzi

PY - 2014/7/4

Y1 - 2014/7/4

N2 - Background: Marijuana has been shown to have an immunomodulatory activity. Results: ChIP-Seq results show genome-wide changes in histone methylation in immune cells treated with THC. Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response. Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.

AB - Background: Marijuana has been shown to have an immunomodulatory activity. Results: ChIP-Seq results show genome-wide changes in histone methylation in immune cells treated with THC. Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response. Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.

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IS - 27

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Histone modifications are associated with 9-tetrahydrocannabinol-mediated alterations in antigenspecific t cell responses

Abstract

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