Histone modifications are associated with 9-tetrahydrocannabinol-mediated alterations in antigenspecific t cell responses

Xiaoming Yang, Venkatesh L. Hegde, Roshni Rao, Jiajia Zhang, Prakash S. Nagarkatti, Mitzi Nagarkatti

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background: Marijuana has been shown to have an immunomodulatory activity. Results: ChIP-Seq results show genome-wide changes in histone methylation in immune cells treated with THC. Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response. Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.

Original languageEnglish (US)
Pages (from-to)18707-18718
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
StatePublished - Jul 4 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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