Histological topographical comparisons of atherosclerosis progression in juveniles and young adults

Satoki Homma, Dana A. Troxclair, Arthur W. Zieske, Gray T. Malcom, Jack P. Strong

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15-34 years) from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and results: The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years. Lesions greater than type 2 were rarely seen in the thoracic aorta. Although type 2 lesions appeared later in the LAD than in the aorta, the lesions within the LAD progressed rapidly to more advanced lesions (types 4 and 5) or atheroma. Lesion development in the abdominal aorta was intermediate to lesion development in the thoracic aorta and the LAD. Conclusions: The most striking topographic difference on lesion progression among the three anatomical sites was the vulnerability of type 2 lesions to progress into advanced lesions. The histology study, including immunohistochemistry limited to the type 2 lesions suggested that lesion progression was related to the intimal thickness and the amount of collagen but not to the number of macrophage foam cells.

Original languageEnglish (US)
Pages (from-to)791-798
Number of pages8
JournalAtherosclerosis
Volume197
Issue number2
DOIs
StatePublished - Apr 2008

Keywords

  • AHA classification
  • Adolescence
  • Aorta
  • Arteriosclerosis
  • Autopsy
  • Collagen
  • Coronary arteries
  • Fatty streaks
  • Histology
  • Histometry
  • Immunohistochemistry
  • Intimal thickness
  • Macrophage
  • PDAY
  • Smooth muscle cells
  • T-lymphocytes
  • Topography
  • Young people

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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