Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres: Report of two cases

Sadhna Dhingra; Myron Schwartz; Edward Kim; Huaibin Mabel Ko; Stephen C. Ward; M. Isabel Fiel; Swan N. Thung

doi:10.1055/s-0034-1394145

Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres: Report of two cases

Sadhna Dhingra, Myron Schwartz, Edward Kim, Huaibin Mabel Ko, Stephen C. Ward, M. Isabel Fiel, Swan N. Thung

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.

Original language	English (US)
Pages (from-to)	465-468
Number of pages	4
Journal	Seminars in Liver Disease
Volume	34
Issue number	4
DOIs	https://doi.org/10.1055/s-0034-1394145
State	Published - Nov 1 2014

Keywords

histology
nontumoral liver
radioembolization
yttrium-90

ASJC Scopus subject areas

Hepatology

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10.1055/s-0034-1394145

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title = "Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres: Report of two cases",

abstract = "Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.",

keywords = "histology, nontumoral liver, radioembolization, yttrium-90",

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T1 - Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres

T2 - Report of two cases

AU - Dhingra, Sadhna

AU - Schwartz, Myron

AU - Kim, Edward

AU - Mabel Ko, Huaibin

AU - Ward, Stephen C.

AU - Fiel, M. Isabel

AU - Thung, Swan N.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.

AB - Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.

KW - histology

KW - nontumoral liver

KW - radioembolization

KW - yttrium-90

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Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

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