Histologic variants of adenocarcinoma and other carcinomas of prostate: Pathologic criteria and clinical significance

Todd L. Randolph, Mahul B. Amin, Jae Y. Ro, Alberto G. Ayala

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations

Abstract

Most cases of carcinoma involving the prostate gland show characteristic acinar histologic features. The term variant is used to describe a distinctly different histomorphologic phenotype of a certain type of neoplasm. The recognition of histologic variants of prostate carcinoma is important because some types are associated with a different clinical outcome and might have a different therapeutic approach, and because awareness of the unusual pattern might be critical in avoiding diagnostic misinterpretations. In this article, we review the subject of histologic variants of prostatic adenocarcinoma with a focus on histologic criteria and clinical significance. We discuss small cell carcinoma, ductal (endometroid) carcinoma, sarcomatoid carcinoma, signet ring cell carcinoma, mucinous carcinoma, lymphoepithelioma-like carcinoma, adenosquamous carcinoma of the prostate, squamous carcinoma, adenoid cystic carcinoma, and transitional cell carcinoma involving the prostate.

Original languageEnglish (US)
Pages (from-to)612-629
Number of pages18
JournalModern Pathology
Volume10
Issue number6
StatePublished - Jun 1997

Keywords

  • Adenocarcinoma
  • Mucinous carcinoma
  • Prostate
  • Prostatic duct adenocarcinoma
  • Sarcomatoid carcinoma
  • Signet ring cell carcinoma
  • Small cell carcinoma
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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