TY - JOUR
T1 - Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone
T2 - A case report and review of literature
AU - Zhang, Da
AU - McGuirk, Joseph
AU - Ganguly, Siddhartha
AU - Persons, Diane L.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/5
Y1 - 2009/5
N2 - Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy. Biopsy of the axillary lymph node showed a low-grade follicular lymphoma. The hipbone lesion was comprised two cell populations, one representing diffuse large B cell lymphoma and the other a histiocytic/dendritic sarcoma. The cells of all three lesions contained an IGH/BCL2 rearrangement, suggesting that both diffuse large B cell lymphoma and histiocytic/dendritic sarcoma differentiation developed from the same low grade precursor (follicular lymphoma). This case illustrates that sarcomatous transdifferentiation of follicular lymphoma can be an unpredictable local phenomenon and that it can occur extra nodally in the bone marrow. It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma.
AB - Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy. Biopsy of the axillary lymph node showed a low-grade follicular lymphoma. The hipbone lesion was comprised two cell populations, one representing diffuse large B cell lymphoma and the other a histiocytic/dendritic sarcoma. The cells of all three lesions contained an IGH/BCL2 rearrangement, suggesting that both diffuse large B cell lymphoma and histiocytic/dendritic sarcoma differentiation developed from the same low grade precursor (follicular lymphoma). This case illustrates that sarcomatous transdifferentiation of follicular lymphoma can be an unpredictable local phenomenon and that it can occur extra nodally in the bone marrow. It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma.
KW - Diffuse large B cell lymphoma
KW - Follicular lymphoma
KW - Histiocytic/dendritic cell sarcomas
KW - T(14;18)
UR - http://www.scopus.com/inward/record.url?scp=67449164510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67449164510&partnerID=8YFLogxK
U2 - 10.1007/s12185-009-0300-y
DO - 10.1007/s12185-009-0300-y
M3 - Article
C2 - 19343479
AN - SCOPUS:67449164510
SN - 0925-5710
VL - 89
SP - 529
EP - 532
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 4
ER -