Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature

Da Zhang, Joseph McGuirk, Siddhartha Ganguly, Diane L. Persons

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy. Biopsy of the axillary lymph node showed a low-grade follicular lymphoma. The hipbone lesion was comprised two cell populations, one representing diffuse large B cell lymphoma and the other a histiocytic/dendritic sarcoma. The cells of all three lesions contained an IGH/BCL2 rearrangement, suggesting that both diffuse large B cell lymphoma and histiocytic/dendritic sarcoma differentiation developed from the same low grade precursor (follicular lymphoma). This case illustrates that sarcomatous transdifferentiation of follicular lymphoma can be an unpredictable local phenomenon and that it can occur extra nodally in the bone marrow. It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma.

Original languageEnglish (US)
Pages (from-to)529-532
Number of pages4
JournalInternational Journal of Hematology
Volume89
Issue number4
DOIs
StatePublished - May 2009

Keywords

  • Diffuse large B cell lymphoma
  • Follicular lymphoma
  • Histiocytic/dendritic cell sarcomas
  • T(14;18)

ASJC Scopus subject areas

  • Hematology

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