Abstract
The duplex formation mediated by Hg 2+ in a properly designed ssDNA generates a stable hairpin structure, which greatly alters the translocation profile of the ssDNA through α-hemolysin nanopore. From the 2D-events contour plot, the presence of Hg 2+ can be confirmed in as little as 30 min at ∼7 nM or higher. The sensor is highly selective to Hg 2+, without interference from other metal ions. It can be fabricated from readily available materials, without the processes of synthesis, purification, probe-making, and so forth. This sensing strategy opens new possibilities for detecting many types of analytes which have specific interactions with DNA molecules.
Original language | English (US) |
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Pages (from-to) | 18312-18317 |
Number of pages | 6 |
Journal | Journal of the American Chemical Society |
Volume | 133 |
Issue number | 45 |
DOIs | |
State | Published - Nov 16 2011 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry