Abstract
Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.
Original language | English (US) |
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Pages (from-to) | 2377-2382 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 57 |
Issue number | 9 |
DOIs | |
State | Published - Feb 23 2018 |
Keywords
- carbon dots
- cellular energy metabolism
- chirality
- glycolysis
- green synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)