TY - JOUR
T1 - Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine
T2 - Affecting Cellular Energy Metabolism
AU - Li, Feng
AU - Li, Yiye
AU - Yang, Xiao
AU - Han, Xuexiang
AU - Jiao, Yang
AU - Wei, Taotao
AU - Yang, Dayong
AU - Xu, Huaping
AU - Nie, Guangjun
PY - 2018/2/23
Y1 - 2018/2/23
N2 - Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.
AB - Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.
KW - carbon dots
KW - cellular energy metabolism
KW - chirality
KW - glycolysis
KW - green synthesis
UR - http://www.scopus.com/inward/record.url?scp=85041649938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041649938&partnerID=8YFLogxK
U2 - 10.1002/anie.201712453
DO - 10.1002/anie.201712453
M3 - Article
C2 - 29359840
AN - SCOPUS:85041649938
VL - 57
SP - 2377
EP - 2382
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 9
ER -