Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

Feng Li; Yiye Li; Xiao Yang; Xuexiang Han; Yang Jiao; Taotao Wei; Dayong Yang; Huaping Xu; Guangjun Nie

doi:10.1002/anie.201712453

Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

Feng Li, Yiye Li, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu, Guangjun Nie

Houston Methodist

Research output: Contribution to journal › Article › peer-review

321 Scopus citations

Abstract

Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.

Original language	English (US)
Pages (from-to)	2377-2382
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	9
DOIs	https://doi.org/10.1002/anie.201712453
State	Published - Feb 23 2018

Keywords

carbon dots
cellular energy metabolism
chirality
glycolysis
green synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201712453

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abstract = "Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.",

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AU - Han, Xuexiang

AU - Jiao, Yang

AU - Wei, Taotao

AU - Yang, Dayong

AU - Xu, Huaping

AU - Nie, Guangjun

PY - 2018/2/23

Y1 - 2018/2/23

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Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

Abstract

Keywords

ASJC Scopus subject areas

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