Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

Feng Li; Yiye Li; Xiao Yang; Xuexiang Han; Yang Jiao; Taotao Wei; Dayong Yang; Huaping Xu; Guangjun Nie

doi:10.1002/anie.201712453

Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

Feng Li, Yiye Li, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu, Guangjun Nie

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.

Original language	English (US)
Pages (from-to)	2377-2382
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	9
DOIs	https://doi.org/10.1002/anie.201712453
State	Published - Feb 23 2018

Keywords

carbon dots
cellular energy metabolism
chirality
glycolysis
green synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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title = "Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism",

abstract = "Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.",

keywords = "carbon dots, cellular energy metabolism, chirality, glycolysis, green synthesis",

author = "Feng Li and Yiye Li and Xiao Yang and Xuexiang Han and Yang Jiao and Taotao Wei and Dayong Yang and Huaping Xu and Guangjun Nie",

note = "Funding Information: This work was supported by projects from the National Basic Research Program of China (2013CB834502), the National Natural Science Funds for Distinguished Young Scholars (31325010, 21425416), NSFC (91543127, 31571021), NSFC Innovation Team (11621505, 21421064), the Key Research Program of CAS (KGZD-EW-T06), and the K. C. Wong Education Foundation. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Jiao, Yang

AU - Wei, Taotao

AU - Yang, Dayong

AU - Xu, Huaping

AU - Nie, Guangjun

N1 - Funding Information: This work was supported by projects from the National Basic Research Program of China (2013CB834502), the National Natural Science Funds for Distinguished Young Scholars (31325010, 21425416), NSFC (91543127, 31571021), NSFC Innovation Team (11621505, 21421064), the Key Research Program of CAS (KGZD-EW-T06), and the K. C. Wong Education Foundation. Publisher Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

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Y1 - 2018/2/23

N2 - Cysteine-based chiral optically active carbon dots (CDs) and their effects on cellular energy metabolism, which is vital for essential cellular functions, have been barely reported. A green and effective synthesis strategy for chiral N-S-doped CDs (fluorescence quantum yield ca. 41.26 %) based on hydrothermal treatment of l- or d-cysteine at as low as 60 °C has been developed. This suggested that cysteine was instable in aqueous solutions and acts as a warning for high-temperature synthesis of nanomaterials using cysteine as stabilizer. Human bladder cancer T24 cells treated with l-CDs showed up-regulated glycolysis, while d-CDs had no similar effects. In contrast, no disturbance to the basal mitochondrial aerobic respiration of T24 cells was caused by either chiral CD.

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Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism

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Keywords

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