Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Kai Yang; Zheng Li; Zhaoyang Wang; Zhiyi Yao; Sheng Jiang

doi:10.1021/ol2016737

Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Kai Yang, Zheng Li, Zhaoyang Wang, Zhiyi Yao, Sheng Jiang

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

Original language	English (US)
Pages (from-to)	4340-4343
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1021/ol2016737
State	Published - Aug 19 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol2016737

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title = "Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides",

abstract = "8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.",

author = "Kai Yang and Zheng Li and Zhaoyang Wang and Zhiyi Yao and Sheng Jiang",

year = "2011",

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doi = "10.1021/ol2016737",

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T1 - Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

AU - Yang, Kai

AU - Li, Zheng

AU - Wang, Zhaoyang

AU - Yao, Zhiyi

AU - Jiang, Sheng

PY - 2011/8/19

Y1 - 2011/8/19

N2 - 8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

AB - 8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

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U2 - 10.1021/ol2016737

DO - 10.1021/ol2016737

M3 - Article

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JO - Organic Letters

JF - Organic Letters

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ER -

Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Abstract

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