Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Kai Yang, Zheng Li, Zhaoyang Wang, Zhiyi Yao, Sheng Jiang

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

Original languageEnglish (US)
Pages (from-to)4340-4343
Number of pages4
JournalOrganic Letters
Volume13
Issue number16
DOIs
StatePublished - Aug 19 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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