Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Kai Yang; Zheng Li; Zhaoyang Wang; Zhiyi Yao; Sheng Jiang

doi:10.1021/ol2016737

Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

Kai Yang, Zheng Li, Zhaoyang Wang, Zhiyi Yao, Sheng Jiang

Research output: Contribution to journal › Article

71 Scopus citations

Abstract

8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

Original language	English (US)
Pages (from-to)	4340-4343
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1021/ol2016737
State	Published - Aug 19 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol2016737

Fingerprint Dive into the research topics of 'Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides'. Together they form a unique fingerprint.

Cite this

@article{7964cf17cf7a4fb8b3a688505a00df7f,

title = "Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides",

abstract = "8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.",

author = "Kai Yang and Zheng Li and Zhaoyang Wang and Zhiyi Yao and Sheng Jiang",

year = "2011",

month = aug,

day = "19",

doi = "10.1021/ol2016737",

language = "English (US)",

volume = "13",

pages = "4340--4343",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "16",

}

TY - JOUR

T1 - Highly efficient synthesis of phenols by copper-catalyzed hydroxylation of aryl iodides, bromides, and chlorides

AU - Yang, Kai

AU - Li, Zheng

AU - Wang, Zhaoyang

AU - Yao, Zhiyi

AU - Jiang, Sheng

PY - 2011/8/19

Y1 - 2011/8/19

N2 - 8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

AB - 8-Hydroxyquinolin-N-oxide was found to be a very efficient ligand for the copper-catalyzed hydroxylation of aryl iodides, aryl bromides, or aryl chlorides under mild reaction conditions. This methodology provides a direct transformation of aryl halides to phenols and to alkyl aryl ethers. The inexpensive catalytic system showed great functional group tolerance and excellent selectivity.

UR - http://www.scopus.com/inward/record.url?scp=80051690322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051690322&partnerID=8YFLogxK

U2 - 10.1021/ol2016737

DO - 10.1021/ol2016737

M3 - Article

C2 - 21786767

AN - SCOPUS:80051690322

VL - 13

SP - 4340

EP - 4343

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 16

ER -