Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

Yuzhen Wang; Yujun Song; Guixian Zhu; Dechen Zhang; Xuewu Liu

doi:10.1016/j.cclet.2017.12.004

Highly biocompatible BSA-MnO₂ nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

Yuzhen Wang, Yujun Song, Guixian Zhu, Dechen Zhang, Xuewu Liu

Research output: Contribution to journal › Article

24 Scopus citations

Abstract

More recently, the biomedical applications of MnO₂ in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO₂ was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO₂ nanoparticles (BSA-MnO₂ NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO₂ NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.

Original language	English (US)
Pages (from-to)	1685-1688
Number of pages	4
Journal	Chinese Chemical Letters
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.cclet.2017.12.004
State	Published - Nov 2018

Keywords

Bovine serum albumin
Cancer therapy
Manganese dioxide
NIR
Photothermal

ASJC Scopus subject areas

Chemistry(all)

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10.1016/j.cclet.2017.12.004

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title = "Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy",

abstract = "More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.",

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AU - Wang, Yuzhen

AU - Song, Yujun

AU - Zhu, Guixian

AU - Zhang, Dechen

AU - Liu, Xuewu

PY - 2018/11

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AB - More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.

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KW - Cancer therapy

KW - Manganese dioxide

KW - NIR

KW - Photothermal

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