TY - JOUR
T1 - Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy
AU - Wang, Yuzhen
AU - Song, Yujun
AU - Zhu, Guixian
AU - Zhang, Dechen
AU - Liu, Xuewu
N1 - Funding Information:
The authors acknowledge financial support from the following sources: National Natural Science Foundation of China (No. 81601632) and the Natural Science Foundation of Jiangsu Province (No. SBK2016041233), the Fundamental Research Funds for Central Universities (No. 021314380067), Thousand Talents Program for Young Researchers, NIH (No. 1R21CA190024-01), DOD (No. W81XWH-12-1-0414) and Houston Methodist Research Institute.
Funding Information:
The authors acknowledge financial support from the following sources: National Natural Science Foundation of China (No. 81601632 ) and the Natural Science Foundation of Jiangsu Province (No. SBK2016041233 ), the Fundamental Research Funds for Central Universities (No. 021314380067 ), Thousand Talents Program for Young Researchers, NIH ( No. 1R21CA190024-01 ), DOD (No. W81XWH-12-1-0414 ) and Houston Methodist Research Institute .
Publisher Copyright:
© 2018 The Author
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.
AB - More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent.
KW - Bovine serum albumin
KW - Cancer therapy
KW - Manganese dioxide
KW - NIR
KW - Photothermal
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U2 - 10.1016/j.cclet.2017.12.004
DO - 10.1016/j.cclet.2017.12.004
M3 - Article
AN - SCOPUS:85041606596
VL - 29
SP - 1685
EP - 1688
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
SN - 1001-8417
IS - 11
ER -