Highlights of pentacyclic triterpenes in the cancer setting

Stephen Safe, Gayathri Chadalapaka, Indira Jutooru, Sudhakar Chintharlapalli, Sabitha Papineni

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Pentacyclic triterpenoid acids including oleanolic, betulinic and ursolic acids and their derivatives, exhibit a wide spectrum of anticancer activities and these include activation of growth inhibitory, proapoptotic and antiangiogenic pathways. Induction of these and other responses undoubtedly involves multiple mechanisms of action; however, it is possible that a more limited number of activities may contribute to their antitumorigenic activity. Studies in this laboratory have demonstrated that several triterpenoid acids or their esters downregulate expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 in several cancer cell lines and tumors. Moreover, decreased expression of Sp proteins is accompanied by decreased expression of Sp-dependent genes associated with growth (cyclin D1 and epidermal growth factor receptor), survival (survivin), and angiogenesis (vascular endothelial growth factor and its receptors). These results demonstrate that an important mechanism of action for triterpenoid acids as anticancer drugs is associated with their downregulation of Sp transcription factors.

Original languageEnglish (US)
Title of host publicationPentacyclic Triterpenes as Promising Agents in Cancer
PublisherNova Science Publishers, Inc.
Pages277-306
Number of pages30
ISBN (Print)9781608769735
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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