TY - JOUR
T1 - Higher Renal Allograft Function in Deceased-Donor Kidney Transplantation Rather Than in Living-Related Kidney Transplantation
AU - Xiong, Y.
AU - Jiang, J.
AU - Zhang, H.
AU - Fu, Q.
AU - Deng, R.
AU - Li, J.
AU - Liu, L.
AU - Yuan, X.
AU - He, X.
AU - Wang, C.
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (No. 81670680, 81300623, 81700655), Science and Technology Planning Project of Guangdong Province, China (2015B020226002, 2014B020212006, 2013B021800292, 2014A020212719), the Natural Science Foundation of Guangdong Province ( 2015A030313135 , 2014A030313022 ), Science and Technology Program of Guangzhou, China (2014Y2-00114), and the Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology (2013A 061401007). We thank Fangchao Yu for his meticulous work on clinical data collection.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10
Y1 - 2018/10
N2 - Objectives: To compare the clinical outcome of kidney transplantation from living-related and deceased donors. Patients and methods: Consecutive adult kidney transplants from living-related or deceased donors from February 2004 to December 2015 in a single center were enrolled for retrospective analysis. Estimated glomerular filtration rate (eGFR) was compared with linear mixed models controlling the effect of repeated measurement at different time points. Results: There were 536 living-related and 524 deceased donor kidney transplants enrolled. The 1-year, 3-year, and 5-year graft survival rates were 98.8%, 98.5% and 97.2% in living-related kidney transplantation (KTx), and 94.9%, 91.3% and 91.3% in deceased donor KTx (log-rank, P <.001). A significantly higher incidence of delayed graft function (DGF) was observed in deceased donor KTx (20.6% vs 2.6%, P <.001). eGFR in deceased donor KTx was significantly higher than that in living-related KTx (68.0 ± 23.7 vs 64.7 ± 17.9 mL/min/1.73 m2 at 1 year postoperation, 70.1 ± 23.3 vs 64.3 ± 19.3 mL/min/1.73 m2 at 2 years postoperation, and 72.5 ± 26.2 vs 65.2 ± 20.4 mL/min/1.73 m2 at 3 years postoperation; P <.001). The donor age was significantly higher in living-related KTx group (47.5 ± 11.0 vs 31.1 ± 14.4 years, P <.001). Conclusion: Living-related graft survival is superior to deceased graft survival at this center, while better 5-year renal allograft function is obtained in deceased donor KTx patients, which may be attributable to the higher age of living-related donors.
AB - Objectives: To compare the clinical outcome of kidney transplantation from living-related and deceased donors. Patients and methods: Consecutive adult kidney transplants from living-related or deceased donors from February 2004 to December 2015 in a single center were enrolled for retrospective analysis. Estimated glomerular filtration rate (eGFR) was compared with linear mixed models controlling the effect of repeated measurement at different time points. Results: There were 536 living-related and 524 deceased donor kidney transplants enrolled. The 1-year, 3-year, and 5-year graft survival rates were 98.8%, 98.5% and 97.2% in living-related kidney transplantation (KTx), and 94.9%, 91.3% and 91.3% in deceased donor KTx (log-rank, P <.001). A significantly higher incidence of delayed graft function (DGF) was observed in deceased donor KTx (20.6% vs 2.6%, P <.001). eGFR in deceased donor KTx was significantly higher than that in living-related KTx (68.0 ± 23.7 vs 64.7 ± 17.9 mL/min/1.73 m2 at 1 year postoperation, 70.1 ± 23.3 vs 64.3 ± 19.3 mL/min/1.73 m2 at 2 years postoperation, and 72.5 ± 26.2 vs 65.2 ± 20.4 mL/min/1.73 m2 at 3 years postoperation; P <.001). The donor age was significantly higher in living-related KTx group (47.5 ± 11.0 vs 31.1 ± 14.4 years, P <.001). Conclusion: Living-related graft survival is superior to deceased graft survival at this center, while better 5-year renal allograft function is obtained in deceased donor KTx patients, which may be attributable to the higher age of living-related donors.
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U2 - 10.1016/j.transproceed.2018.03.041
DO - 10.1016/j.transproceed.2018.03.041
M3 - Article
C2 - 30316368
AN - SCOPUS:85054454406
SN - 0041-1345
VL - 50
SP - 2412
EP - 2415
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 8
ER -