High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy

Wenyan Yin, Liang Yan, Jie Yu, Gan Tian, Liangjun Zhou, Xiaopeng Zheng, Xiao Zhang, Yuan Yong, Juan Li, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

655 Scopus citations

Abstract

We report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating MoS2 nanosheets with chitosan, these functionalized MoS2 nanosheets have been developed as a chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy. Loaded doxorubicin could be controllably released upon the photothermal effect induced by 808 nm NIR laser irradiation. In vitro and in vivo tumor ablation studies demonstrate a better synergistic therapeutic effect of the combined treatment, compared with either chemotherapy or photothermal therapy alone. Finally, MoS2 nanosheets can also be used as a promising contrast agent in X-ray computed tomography imaging due to the obvious X-ray absorption ability of Mo. As a result, the high-throughput oleum treatment exfoliation process could be extended for fabricating other 2D nanomaterials, and the NIR-triggered drug release strategy was encouraging for simultaneous imaging-guided cancer theranostic application.

Original languageEnglish (US)
Pages (from-to)6922-6933
Number of pages12
JournalACS Nano
Volume8
Issue number7
DOIs
StatePublished - Jul 22 2014

Keywords

  • exfoliation strategy
  • high-throughput
  • NIR-triggered drug delivery
  • oleum treatment

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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