High-temporal resolution dual-energy computed tomography of the heart using a novel hybrid image reconstruction algorithm: Initial experience

John William Nance, Gorka Bastarrika, Doo Kyoung Kang, Balazs Ruzsics, Sebastian Vogt, Bernhard Schmidt, Rainer Raupach, Thomas G. Flohr, U. Joseph Schoepf

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Objectives: Dual-energy computed tomography (DECT) has been proposed for the comprehensive assessment of coronary artery stenosis and myocardial perfusion yet traditionally required reducing the temporal resolution of cardiac studies. We evaluated a reconstruction algorithm that preserves high temporal resolution at cardiac DECT. Methods: Twelve consecutive patients (3 women; mean [SD] age, 64 [10] years) with an abnormal single photon emission CT result underwent invasive coronary angiography and cardiac DECT. Dual-energy CT studies were reconstructed using the standard algorithm with 165-millisecond temporal resolution and a hybrid algorithm providing 83-millisecond temporal resolution. These studies were rated for coronary image quality and motion artifacts and compared with invasive coronary angiographic studies. Results: One hundred sixty-eight coronary artery segments (82%) were evaluated. The standard 165-millisecond reconstruction provided 95% diagnostic segments compared with 100% using the 83-millisecond hybrid reconstruction. Image quality was rated significantly (P < 0.05) better with hybrid reconstruction and had 91.4% sensitivity, 94.7% specificity, 82.1% positive predictive value, and 97.7% negative predictive value for detecting significant stenosis versus 85.7%, 93.2%, 76.9%, and 96.1% with standard reconstruction, respectively. Conclusions: Hybrid image reconstruction mitigates the former limitations in temporal resolution of cardiac DECT.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalJournal of Computer Assisted Tomography
Issue number1
StatePublished - 2011


  • Dual-energy computed tomography
  • coronary artery disease
  • reconstruction algorithms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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