High spatial correspondence at a columnar level between activation and resting state fMRI signals and local field potentials

Zhaoyue Shi, Ruiqi Wu, Pai Feng Yang, Feng Wang, Tung Lin Wu, Arabinda Mishra, Li Min Chen, John C. Gore

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Although blood oxygenation level-dependent (BOLD) fMRI has been widely used to map brain responses to external stimuli and to delineate functional circuits at rest, the extent to which BOLD signals correlate spatially with underlying neuronal activity, the spatial relationships between stimulus-evoked BOLD activations and local correlations of BOLD signals in a resting state, and whether these spatial relationships vary across functionally distinct cortical areas are not known. To address these critical questions, we directly compared the spatial extents of stimulated activations and the local profiles of intervoxel resting state correlations for both high-resolution BOLD at 9.4 T and local field potentials (LFPs), using 98-channel microelectrode arrays, in functionally distinct primary somatosensory areas 3b and 1 in nonhuman primates. Anatomic images of LFP and BOLD were coregistered within 0.10 mm accuracy. We found that the point spread functions (PSFs) of BOLD and LFP responses were comparable in the stimulus condition, and both estimates of activations were slightly more spatially constrained than local correlations at rest. The magnitudes of stimulus responses in area 3b were stronger than those in area 1 and extended in a medial to lateral direction. In addition, the reproducibility and stability of stimulus-evoked activation locations within and across both modalities were robust. Our work suggests that the intrinsic resolution of BOLD is not a limiting feature in practice and approaches the intrinsic precision achievable by multielectrode electrophysiology.

Original languageEnglish (US)
Pages (from-to)5233-5258
Number of pages26
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number20
DOIs
StatePublished - May 16 2017

Keywords

  • BOLD fMRI
  • Local field potential
  • Point spread function
  • Primary somatosensory cortex
  • Resting state correlations

ASJC Scopus subject areas

  • General

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