High-risk HPV testing in women 30 years or older with negative papanicolaou tests: Initial clinical experience with 18-month follow-up

Michael J. Thrall, Donna K. Russell, Michael S. Facik, Jorge L. Yao, Julie Ann N. Warner, Thomas A. Bonfiglio, Ellen J. Giampoli

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Cervical screening with combined cytology and high-risk human papillomavirus (HR-HPV) detection has been approved for women 30 years or older. We investigated the clinical use of cotesting for women with negative Papanicolaou tests. Follow-up cytology, HR-HPV test, and biopsy findings were identified during an 18-month period. In 1 year, 2,719 cotests from 2,686 women were identified; 146 were positive for HR-HPV. Among women with positive HR-HPV testing, 120 had follow-up, including 70 with repeated cotesting, and 3 had high-grade dysplasia identified (2.5% of women with follow-up). In 1,334 women with initial double-negative cotest results who had repeated cytologic testing within 18 months, 2 high-grade dysplasias were found (0.1%). The vast majority of cotest results are doublenegative. Among tests that show HR-HPV positivity, the prevalence of underlying high-grade dysplasia is low. About half of all women who undergo cotesting receive follow-up that is not in accord with published guidelines.

Original languageEnglish (US)
Pages (from-to)894-898
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume133
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • HPV
  • Human papillomavirus
  • Negative for intraepithelial lesion or malignancy
  • NILM
  • Papanicolaou test

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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