High-resolution in vivo CBV mapping with MRI in wild-type mice

Ed X. Wu; Kelvin K. Wong; Martin Andrassy; Haiying Tang

doi:10.1002/mrm.10425

High-resolution in vivo CBV mapping with MRI in wild-type mice

Ed X. Wu, Kelvin K. Wong, Martin Andrassy, Haiying Tang

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

NMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild-type mice. The CBV mapping was based on changes in the steady-state NMR transverse relaxation rate (ΔR₂) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm x 100 μm x 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The ΔR₂ dosage dependency and MION tissue clearance in mouse are also reported.

Original language	English (US)
Pages (from-to)	765-770
Number of pages	6
Journal	Magnetic Resonance in Medicine
Volume	49
Issue number	4
DOIs	https://doi.org/10.1002/mrm.10425
State	Published - Apr 1 2003

Keywords

C57BL6/J
CBV
Cerebral blood volume
MION
Mouse

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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10.1002/mrm.10425

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High-resolution in vivo CBV mapping with MRI in wild-type mice

Abstract

Keywords

ASJC Scopus subject areas

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