High-resolution in vivo CBV mapping with MRI in wild-type mice

Ed X. Wu, Kelvin K. Wong, Martin Andrassy, Haiying Tang

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

NMR microimaging has the potential to elucidate cerebrovascular abnormalities in mouse models. In this study, the relative regional cerebral blood volume (CBV) map is presented for C57BL6/J wild-type mice. The CBV mapping was based on changes in the steady-state NMR transverse relaxation rate (ΔR2) associated with the presence of a superparamagnetic intravascular contrast agent (MION) with a long blood halflife. The experiments were performed at 9.4 T at a voxel size of 100 μm x 100 μm x 600 μm. Fine details, such as the hippocampal and olfactory bulb area, were visualized in the CBV map. The relative regional CBV values of various brain regions were measured. The ΔR2 dosage dependency and MION tissue clearance in mouse are also reported.

Original languageEnglish (US)
Pages (from-to)765-770
Number of pages6
JournalMagnetic Resonance in Medicine
Volume49
Issue number4
DOIs
StatePublished - Apr 1 2003

Keywords

  • C57BL6/J
  • CBV
  • Cerebral blood volume
  • MION
  • Mouse

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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