High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center

Samuel L. Aitken; Jeffrey J. Tarrand; Lalitagauri M. Deshpande; Frank P. Tverdek; Anne L. Jones; Samuel A. Shelburne; Randall A. Prince; Micah M. Bhatti; Kenneth V.I. Rolston; Ronald N. Jones; Mariana Castanheira; Roy F. Chemaly

doi:10.1093/cid/ciw398

High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center

Samuel L. Aitken, Jeffrey J. Tarrand, Lalitagauri M. Deshpande, Frank P. Tverdek, Anne L. Jones, Samuel A. Shelburne, Randall A. Prince, Micah M. Bhatti, Kenneth V.I. Rolston, Ronald N. Jones, Mariana Castanheira, Roy F. Chemaly

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Resistance to the novel β-lactam/β-lactamase inhibitor combination ceftazidime-avibactam (CAZ-AVI) among carbapenem-resistant Enterobacteriaceae (CRE) has infrequently been reported in the United States. We report unexpectedly high rates of resistance to CAZ-AVI in CRE bloodstream isolates at our institution associated with the nonoutbreak spread of New Delhi metallo-β-lactamase in diverse Enterobacteriaceae species.

Original language	English (US)
Pages (from-to)	954-958
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	63
Issue number	7
DOIs	https://doi.org/10.1093/cid/ciw398
State	Published - Oct 1 2016

Keywords

CRE
NDM
bacteremia
carbapenemase
ceftazidime-avibactam

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciw398

Cite this

Aitken, S. L., Tarrand, J. J., Deshpande, L. M., Tverdek, F. P., Jones, A. L., Shelburne, S. A., Prince, R. A., Bhatti, M. M., Rolston, K. V. I., Jones, R. N., Castanheira, M., & Chemaly, R. F. (2016). High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. Clinical Infectious Diseases, 63(7), 954-958. https://doi.org/10.1093/cid/ciw398

High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. / Aitken, Samuel L.; Tarrand, Jeffrey J.; Deshpande, Lalitagauri M. et al.

In: Clinical Infectious Diseases, Vol. 63, No. 7, 01.10.2016, p. 954-958.

Research output: Contribution to journal › Article › peer-review

Aitken, SL, Tarrand, JJ, Deshpande, LM, Tverdek, FP, Jones, AL, Shelburne, SA, Prince, RA, Bhatti, MM, Rolston, KVI, Jones, RN, Castanheira, M & Chemaly, RF 2016, 'High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center', Clinical Infectious Diseases, vol. 63, no. 7, pp. 954-958. https://doi.org/10.1093/cid/ciw398

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abstract = "Resistance to the novel β-lactam/β-lactamase inhibitor combination ceftazidime-avibactam (CAZ-AVI) among carbapenem-resistant Enterobacteriaceae (CRE) has infrequently been reported in the United States. We report unexpectedly high rates of resistance to CAZ-AVI in CRE bloodstream isolates at our institution associated with the nonoutbreak spread of New Delhi metallo-β-lactamase in diverse Enterobacteriaceae species.",

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High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center

Abstract

Keywords

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