High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

Qian Dou, Debo Hu, Hongkai Gao, Yongmei Zhang, Ali K. Yetisen, Haider Butt, Jing Wang, Guangjun Nie, Qing Dai

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Rapid and robust hydrogels are essential in realizing continuous glucose monitoring in diabetes monitoring. However, existing hydrogels are limited in satisfying all of the sensory requirements such as detection range, response time, recoverability and biocompatibility. Here, we have developed a surface-initiated polymerization method to chemically immobilize a nano-boronic acid-hydrogel membrane onto a quartz crystal, then used a quartz crystal microbalance (QCM) to achieve real-time monitoring of glucose. The experimental results show that this hydrogel possesses enhanced binding properties to glucose under physiological conditions (pH 7.0-7.5) and blood glucose concentration (BGC) (1.1-33.3 mM). Moreover, our hydrogel displayed a rapid response time (∼100 s) to glucose, high biocompatibility in vivo through an animal model. The hydrogel has a great potential as a sensitive glucose probe for implantable continuous glucose sensors.

Original languageEnglish (US)
Pages (from-to)41384-41390
Number of pages7
JournalRSC Advances
Volume7
Issue number66
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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