High levels of immunoglobulin expression predict shorter overall survival in patients with acute myeloid leukemia

Lina Wu, Miaoran Xia, Xiaoping Sun, Xin Han, Youli Zu, Elias J. Jabbour, M. James You, Pei Lin, Shaoying Li, Jie Xu, Haibo Han, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Xiaoyan Qiu, C. Cameron Yin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objectives: It has been believed that immunoglobulins can only be produced by B lymphocytes and plasma cells. We have previously reported that IgG can be expressed in myeloblasts from patients with acute myeloid leukemia (AML) and plays a role in the proliferation and apoptosis of leukemic cells. However, its clinical impact has not been assessed. Methods: We assessed the expression of different classes of immunoglobulin in peripheral blood and bone marrow samples from 132 AML patients and correlated the levels of expression with clinicopathologic and molecular genetic features, as well as clinical outcome. Results: We found that, in addition to IgG, all classes of immunoglobulin are expressed in myeloblasts, including IgG, IgM, IgA, IgD, IgE, Igκ, and Igλ. The levels of IgG expression (coupled with Igκ or Igλ) are higher than those of IgM, IgA, IgD, and IgE. Using receiver operating characteristic (ROC) curve analysis, we identified two distinct groups of AML patients with differential expression of immunoglobulin and different clinical outcomes. Conclusions: High levels of immunoglobulin expression are associated with monocytic differentiation, multilineage dysplasia, TET2 and KRAS mutations, and poor overall survival. Assessment of immunoglobulin may serve as a useful marker for prognostic stratification and target therapy.

Original languageEnglish (US)
Pages (from-to)449-459
Number of pages11
JournalEuropean Journal of Haematology
Issue number4
StatePublished - Oct 1 2020


  • acute myeloid leukemia
  • immunoglobulin
  • overall survival

ASJC Scopus subject areas

  • Hematology


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