High-level CD34 expression on megakaryocytes independently predicts an adverse outcome in patients with myelodysplastic syndromes

Guilin Tang, Sa A. Wang, Madhu Menon, Karen Dresser, Bruce A. Woda, Suyang Hao

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Expression of CD34 on mature-appearing megakaryocytes can be seen in various intrinsic bone marrow (BM) disorders as well as reactive bone marrows. In this study we investigate the clinical significance of CD34+ megakaryocytes in myelodysplastic syndromes (MDSs). Expression of CD34 on megakaryocytes was assessed on BM biopsies obtained from 202 patients with MDS. High-level (≥20%) CD34 expression on megakaryocytes was found in BM of 29 patients (14%). The expression of CD34 on megakaryocytes is correlated with severe cytopenia, higher numbers of myeloblasts, more frequent and higher risk cytogenetic abnormalities, and a shorter overall survival. Multivariate analysis indicated that the expression of CD34 on megakaryocytes could be a strong and an independent poor prognostic factor in MDS, with a hazard ratio of 2.53.

Original languageEnglish (US)
Pages (from-to)766-770
Number of pages5
JournalLeukemia Research
Volume35
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • CD34 expression
  • Megakaryocytes
  • Myelodysplastic syndromes
  • Prognostic factor
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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