High-grade cervical dysplasia following radiation therapy for invasive cervical cancer: A report of four cases

Mila Pontremoli Salcedo, Andrea M. Milbourne, Anuja Jhingran, Patricia J. Eifel, Pedro T. Ramirez, Kathleen M. Schmeler

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: The standard treatment for locally advanced cervical cancer is chemoradiation, with the majority of patients having a complete response to the therapy. The current surveillance recommendations from the Society of Gynecologic Oncology include annual cytology, with a small proportion of patients subsequently diagnosed with high-grade cervical dysplasia (CIN 2/3). To date, there is limited information regarding the optimal treatment and outcome for patients diagnosed with CIN 2/3. The current report describes the diagnosis, management and outcome of 4 patients diagnosed with CIN 2/3 following chemoradiation. Case Description: We describe 4 patients who developed CIN 2/3 seven months to 8 years following radiation therapy for locally advanced cervical cancer. All 4 patients were asymptomatic and the abnormalities were first detected by a Pap test. Three of the patients were managed conservatively with observation, and the CIN 2/3 resolved without intervention. One patient underwent 2 cervical conizations followed by a hysterectomy with no residual dysplasia noted on the hysterectomy specimen. Conclusion: The majority of patients with recurrent cervical cancer after chemoradiation are symptomatic, and most cases are detected by a physical examination. The role of cytology, colposcopy and biopsies may be of limited value. Furthermore, the significance of the diagnosis of CIN 2/3 in patients previously treated with radiation therapy was not associated with recurrent disease in the 4 patients described. Our results suggest that cytology may be of limited value in detecting recurrence in patients following radiation therapy, even when CIN 2/3 is detected.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalCase Reports in Oncology
StatePublished - May 6 2015


  • Cervical cancer
  • Cervical dysplasia
  • Cold knife cone
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'High-grade cervical dysplasia following radiation therapy for invasive cervical cancer: A report of four cases'. Together they form a unique fingerprint.

Cite this