@article{251f10aaaaad45e8bf092800a254b37c,
title = "High frequency germline acquisition of ecotropic MuLV proviruses in SWR/J-RF/J hybrid mice",
abstract = "RF/J mice carry three endogenous ecotropic murine leukemia proviruses designated Emv-1, Emv-16, and Emv-17. Two of these proviruses, Emv-16 and Emv-17, are tightly linked and segregate with the high viremia phenotype in backcrossed mice. During the derivation of an SWR/J strain congenic for Emv-16 and Emv-17, we found that many of the progeny derived from female virus carriers acquired new germline ecotropic proviruses. Additional genetic crosses suggested that these proviruses are acquired early in development by virus infection and that this strain combination is particularly susceptible to these events. The frequency of proviral acquisition was only about 10-fold lower than the frequency of P element acquisition in dysgenic crosses of Drosophila melanogaster. Since virus integration in these hybrids occurs at many different sites, these types of hybrids may ultimately be useful for generating virally induced mutations that are amenable to study at the molecular level.",
author = "Jenkins, {Nancy A.} and Copeland, {Neal G.}",
note = "Funding Information: We thank Earl L. Green (Bar Harbor, Maine) for his computer program (CRPBYRXS) for calculating the recombination probability by use of Fisher{\textquoteright}s scores, Barbara Lee and Marie Menzietti (The Jackson Laboratory), and Debbie Swing and Charles Sabatos (University of Cincinnati and NC&Frederick Cancer Research Facility) for expert technical assistance, and Linda Brubaker (NCCFrederick Cancer Research Facility) for typing this manuscript. We are grateful to Victoria Bautch (Cold Spring Harbor Laboratory) for many helpful discussions and to Stephen Hughes and Stephen O{\textquoteright}Brien for review of the manuscript. This research was supported by National Cancer Institute grants CA-38039 and CA-37283, American Cancer Society grant MV-124, and by the National Cancer Institute, Department of Health and Human Services, under contract no. NOl-CO-23909 with Litton Bionetics, Inc. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.",
year = "1985",
month = dec,
doi = "10.1016/0092-8674(85)90254-5",
language = "English (US)",
volume = "43",
pages = "811--819",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3 PART 2",
}