High-Dose Vitamin A Therapy for Darier's Disease

J. Raymond Thomas, John P. Cooke, R. K. Winkelmann

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Three patients with Darier's disease were treated with 1 x 106 IU of orally administered vitamin A daily for 14 days. In all patients, 50% to 80% improvement in the skin lesions was noted. Desquamation was minimal, and side effects consisted of drowsiness, mild frontal headache, dry lips, and dry nose. During therapy, all patients had a transient, mild increase in the serum triglyceride level, and two patients had a minimal increase in the serum cholesterol concentration.

Original languageEnglish (US)
Pages (from-to)891-894
Number of pages4
JournalArchives of Dermatology
Issue number11
StatePublished - Nov 1982

ASJC Scopus subject areas

  • Dermatology


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