High-dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years

Martha Arellano, Elliott Winton, Lin Pan, Lisa Lima, Mourad Tighiouart, Kapil Bhalla, Leonard T. Heffner, Jessica Neely, Donald Hutcherson, Morgan McLemore, Amelia Langston, H. Jean Khoury

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

BACKGROUND: High-dose cytarabine (HiDAC) is safe and very effective in younger patients with acute myeloid leukemia (AML), but it generally is not well tolerated in the elderly. METHODS: The authors explored the safety and tolerability of a modified HiDAC induction regimen consisting of 6 daily doses of cytarabine at 2 g/m 2 in combination with 3 daily doses of daunorubicin at 45 mg/m 2 in 59 consecutive patients aged >60 years who had de novo AML diagnosed between July 1996 and February 2005. RESULTS: The median patient age was 68 years (range, 60-86 years). The regimen was well tolerated. Infections were common and occurred in 39% of patients, but cerebellar toxicities occurred in only 7% of patients and were reversible. The day-30 induction-related mortality rate was 10%. Overall, 69% of patients achieved complete remissions (CR), and 80% received up to 3 consolidations with HiDAC. The median follow-up for surviving patients was 53 months (range, 17-114 months). The median overall survival was 15.3 months (range, 1-114 months), and the relapse-free survival was 13.8 months (range, 1-113 months). Survival for patients who achieved CR was 27 months (range, 2-114 months). CONCLUSIONS: The modified HiDAC regimen was well tolerated in patients aged >60 years with AML and was associated with low induction mortality and high rates of CR. Nevertheless, these high remissions still were associated with poor overall outcomes.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalCancer
Volume118
Issue number2
DOIs
StatePublished - Jan 15 2012

Keywords

  • Acute myeloid leukemia
  • Cytarabine
  • Elderly
  • High-dose cytarabine
  • Outcomes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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