TY - JOUR
T1 - High beta activity in the subthalamic nucleus and freezing of gait in Parkinson's disease
AU - Toledo, Jon B.
AU - López-Azcárate, Jon
AU - Garcia-Garcia, David
AU - Guridi, Jorge
AU - Valencia, Miguel
AU - Artieda, Julio
AU - Obeso, Jose
AU - Alegre, Manuel
AU - Rodriguez-Oroz, Maria
N1 - Funding Information:
Dr Valencia received funding from the Spanish Ministry of Science and Innovation (Project Ref. BFU2010-18608) and from the Spanish Ministry of Science and Innovation, Juan de la Cierva program (Project Ref. JCI-2010-07876 ).
Funding Information:
This study is supported by the Spanish Ministry of Science and Innovation (Project Ref. BFU2010-18608 ).
PY - 2014/4
Y1 - 2014/4
N2 - Objective: Oscillatory activity in the beta band is increased in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients. Rigidity and bradykinesia are associated with the low-beta component (13-20. Hz) but the neurophysiological correlate of freezing of gait in PD has not been ascertained. Methods: We evaluated the power and coherence of the low- and high-beta bands in the STN and cortex (EEG) of PD patients with (p-FOG) (n = 14) or without freezing of gait (n-FOG) (n = 8) in whom electrodes for chronic stimulation in the STN had been implanted for treatment with deep brain stimulation. Results: p-FOG patients showed higher power in the high-beta band (F=11.6, p=0.002) that was significantly reduced after l-dopa administration along with suppression of FOG (F=4.6, p=0.042). High-beta cortico-STN coherence was maximal for midline cortical EEG electrodes, whereas the low-beta band was maximal for lateral electrodes (χ2=20.60, p<0.0001). Conclusions: The association between freezing of gait, high-beta STN oscillations and cortico-STN coherence suggests that this oscillatory activity might interfere in the frontal cortex-basal ganglia networks, thereby participating in the pathophysiology of FOG in PD.
AB - Objective: Oscillatory activity in the beta band is increased in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients. Rigidity and bradykinesia are associated with the low-beta component (13-20. Hz) but the neurophysiological correlate of freezing of gait in PD has not been ascertained. Methods: We evaluated the power and coherence of the low- and high-beta bands in the STN and cortex (EEG) of PD patients with (p-FOG) (n = 14) or without freezing of gait (n-FOG) (n = 8) in whom electrodes for chronic stimulation in the STN had been implanted for treatment with deep brain stimulation. Results: p-FOG patients showed higher power in the high-beta band (F=11.6, p=0.002) that was significantly reduced after l-dopa administration along with suppression of FOG (F=4.6, p=0.042). High-beta cortico-STN coherence was maximal for midline cortical EEG electrodes, whereas the low-beta band was maximal for lateral electrodes (χ2=20.60, p<0.0001). Conclusions: The association between freezing of gait, high-beta STN oscillations and cortico-STN coherence suggests that this oscillatory activity might interfere in the frontal cortex-basal ganglia networks, thereby participating in the pathophysiology of FOG in PD.
KW - Beta activity
KW - Freezing of gait
KW - Oscillatory activity
KW - Parkinson's disease
KW - Subthalamic nucleus
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U2 - 10.1016/j.nbd.2013.12.005
DO - 10.1016/j.nbd.2013.12.005
M3 - Article
C2 - 24361601
AN - SCOPUS:84892452384
SN - 0969-9961
VL - 64
SP - 60
EP - 65
JO - Neurobiology of Disease
JF - Neurobiology of Disease
ER -