HFE mutations are not strongly associated with sporadic ALS

A. A. Yen; Ericka P. Greene; J. S. Henkel; David Beers; Stanley H. Appel

doi:10.1212/01.WNL.0000123114.04644.CC

HFE mutations are not strongly associated with sporadic ALS

A. A. Yen, Ericka P. Greene, J. S. Henkel, David Beers, Stanley H. Appel

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40 Scopus citations

Abstract

The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress. The prevalence of the C282Y and H63D mutations was nearly identical in 51 ALS patients and 47 normal control subjects. The presence of either mutation did not significantly affect the age at onset or rate of progression in ALS.

Original language	English (US)
Pages (from-to)	1611-1612
Number of pages	2
Journal	Neurology
Volume	62
Issue number	9
DOIs	https://doi.org/10.1212/01.WNL.0000123114.04644.CC
State	Published - May 11 2004

ASJC Scopus subject areas

Clinical Neurology

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abstract = "The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress. The prevalence of the C282Y and H63D mutations was nearly identical in 51 ALS patients and 47 normal control subjects. The presence of either mutation did not significantly affect the age at onset or rate of progression in ALS.",

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AU - Yen, A. A.

AU - Greene, Ericka P.

AU - Henkel, J. S.

AU - Beers, David

AU - Appel, Stanley H.

PY - 2004/5/11

Y1 - 2004/5/11

N2 - The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress. The prevalence of the C282Y and H63D mutations was nearly identical in 51 ALS patients and 47 normal control subjects. The presence of either mutation did not significantly affect the age at onset or rate of progression in ALS.

AB - The presence of oxidative damage and increased iron deposition in CNS tissues of ALS patients prompted the authors to examine the prevalence of two common HFE gene mutations linked to iron accumulation and consequent oxidative stress. The prevalence of the C282Y and H63D mutations was nearly identical in 51 ALS patients and 47 normal control subjects. The presence of either mutation did not significantly affect the age at onset or rate of progression in ALS.

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JO - Neurology

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HFE mutations are not strongly associated with sporadic ALS

Abstract

ASJC Scopus subject areas

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