Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature

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6 Scopus citations


Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. Despite early clinical deterioration, prompt initiation of therapy with intravenous acyclovir and methylprednisolone led to rapid improvement.

Original languageEnglish (US)
Article number8613840
JournalCase Reports in Medicine
StatePublished - 2020

ASJC Scopus subject areas

  • Medicine(all)


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