Heritability of venous biomechanics

Research output: Contribution to journalArticle

Andrea Ágnes Molnár, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Zoltán Kulcsár, Levente Littvay, Zsolt Garami, István Préda, Róbert Gábor Kiss, Viktor Bérczi, Ágnes Lannert, Emil Monos, György László Nádasy

Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3% genetic component of the variance of low pressure, 37.9% of high-pressure venous capacity, and 36.4% of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0%-81.4%). Conclusion-Femoral vein capacity and elasticity depend 30% to 40% on genetic factors, and this value in the standing body position can reach 50%. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2013

PMID: 23117659

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Heritability of venous biomechanics. / Molnár, Andrea Ágnes; Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Kulcsár, Zoltán; Littvay, Levente; Garami, Zsolt; Préda, István; Kiss, Róbert Gábor; Bérczi, Viktor; Lannert, Ágnes; Monos, Emil; Nádasy, György László.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 33, No. 1, 01.01.2013, p. 152-157.

Research output: Contribution to journalArticle

Harvard

Molnár, AÁ, Tárnoki, ÁD, Tárnoki, DL, Kulcsár, Z, Littvay, L, Garami, Z, Préda, I, Kiss, RG, Bérczi, V, Lannert, Á, Monos, E & Nádasy, GL 2013, 'Heritability of venous biomechanics' Arteriosclerosis, thrombosis, and vascular biology, vol. 33, no. 1, pp. 152-157. https://doi.org/10.1161/ATVBAHA.112.300062

APA

Molnár, A. Á., Tárnoki, Á. D., Tárnoki, D. L., Kulcsár, Z., Littvay, L., Garami, Z., ... Nádasy, G. L. (2013). Heritability of venous biomechanics. Arteriosclerosis, thrombosis, and vascular biology, 33(1), 152-157. https://doi.org/10.1161/ATVBAHA.112.300062

Vancouver

Molnár AÁ, Tárnoki ÁD, Tárnoki DL, Kulcsár Z, Littvay L, Garami Z et al. Heritability of venous biomechanics. Arteriosclerosis, thrombosis, and vascular biology. 2013 Jan 1;33(1):152-157. https://doi.org/10.1161/ATVBAHA.112.300062

Author

Molnár, Andrea Ágnes ; Tárnoki, Ádám Domonkos ; Tárnoki, Dávid László ; Kulcsár, Zoltán ; Littvay, Levente ; Garami, Zsolt ; Préda, István ; Kiss, Róbert Gábor ; Bérczi, Viktor ; Lannert, Ágnes ; Monos, Emil ; Nádasy, György László. / Heritability of venous biomechanics. In: Arteriosclerosis, thrombosis, and vascular biology. 2013 ; Vol. 33, No. 1. pp. 152-157.

BibTeX

@article{f45e53c3ab6f4988a439791b02e46908,
title = "Heritability of venous biomechanics",
abstract = "Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3{\%} genetic component of the variance of low pressure, 37.9{\%} of high-pressure venous capacity, and 36.4{\%} of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0{\%}-81.4{\%}). Conclusion-Femoral vein capacity and elasticity depend 30{\%} to 40{\%} on genetic factors, and this value in the standing body position can reach 50{\%}. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.",
keywords = "biomechanics, heritability, ultrasound, Valsalva, vein, venous",
author = "Moln{\'a}r, {Andrea {\'A}gnes} and T{\'a}rnoki, {{\'A}d{\'a}m Domonkos} and T{\'a}rnoki, {D{\'a}vid L{\'a}szl{\'o}} and Zolt{\'a}n Kulcs{\'a}r and Levente Littvay and Zsolt Garami and Istv{\'a}n Pr{\'e}da and Kiss, {R{\'o}bert G{\'a}bor} and Viktor B{\'e}rczi and {\'A}gnes Lannert and Emil Monos and N{\'a}dasy, {Gy{\"o}rgy L{\'a}szl{\'o}}",
year = "2013",
month = "1",
day = "1",
doi = "10.1161/ATVBAHA.112.300062",
language = "English",
volume = "33",
pages = "152--157",
journal = "Arteriosclerosis, thrombosis, and vascular biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Heritability of venous biomechanics

AU - Molnár, Andrea Ágnes

AU - Tárnoki, Ádám Domonkos

AU - Tárnoki, Dávid László

AU - Kulcsár, Zoltán

AU - Littvay, Levente

AU - Garami, Zsolt

AU - Préda, István

AU - Kiss, Róbert Gábor

AU - Bérczi, Viktor

AU - Lannert, Ágnes

AU - Monos, Emil

AU - Nádasy, György László

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3% genetic component of the variance of low pressure, 37.9% of high-pressure venous capacity, and 36.4% of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0%-81.4%). Conclusion-Femoral vein capacity and elasticity depend 30% to 40% on genetic factors, and this value in the standing body position can reach 50%. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.

AB - Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3% genetic component of the variance of low pressure, 37.9% of high-pressure venous capacity, and 36.4% of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0%-81.4%). Conclusion-Femoral vein capacity and elasticity depend 30% to 40% on genetic factors, and this value in the standing body position can reach 50%. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.

KW - biomechanics

KW - heritability

KW - ultrasound

KW - Valsalva

KW - vein

KW - venous

UR - http://www.scopus.com/inward/record.url?scp=84871744800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871744800&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.112.300062

DO - 10.1161/ATVBAHA.112.300062

M3 - Article

VL - 33

SP - 152

EP - 157

JO - Arteriosclerosis, thrombosis, and vascular biology

T2 - Arteriosclerosis, thrombosis, and vascular biology

JF - Arteriosclerosis, thrombosis, and vascular biology

SN - 1079-5642

IS - 1

ER -

ID: 3316273